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TABLE 4 Mechanism of action and level of observed therapeutic benefits of semi-synthetic and synthetic AT mentioned in this review

The main related signaling pathways and transformation factors are summarized as follows: NF-B, MAPK signaling pathway, JAK2/STAT3 signaling pathway, PI3K/Akt signaling pathway, AP-1, Nrf2, SIRT1, and HIF-1

Dysregulation and epigenetic reprogramming of NRF2 signaling axis promote acquisition of cisplatin resistance and metastasis in head and neck squamous cell carcinoma

it simultaneously provides the exact raw materials and enzymatic cofactors the body needs to rebuild its own endogenous (internal) supply

Blair, L

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